Polyquaternium-51
Product Name:Polyquaternium-51 Appearance:Clear to pale yellow viscous liquid / Powder Specification / Grade:Cosmetic Grade / Raw Material Sample:Available upon request Shelf Life:24 Months Storage:Store in a cool, dry place away from direct sunlight
Products Description
Polyquaternium-51 is an advanced biocompatible copolymer composed of 2-methacryloyloxyethyl phosphorylcholine (MPC) and butyl methacrylate. Known for mimicking the structure of human cell membranes, this premium cosmetic raw material delivers exceptional moisture retention and cellular protection. Its unique zwitterionic structure allows it to form a breathable, highly stable hydration barrier on the skin and hair surface, significantly outperforming traditional humectants like hyaluronic acid in sustained moisture delivery. Primarily utilized in high-end skincare, hair care, and daily chemical formulations, it is favored for its ability to restore barrier function and impart a smooth, non-sticky tactile feel.
As an established manufacturer and raw material supplier, Xi'an Hao Ze Bio Technology Co., Ltd. offers comprehensive B2B partnership solutions, including bulk Polyquaternium-51 supply, custom synthesis, and private label OEM/ODM services. We support cosmetic brands, formulators, and global distributors with rigorous quality control, stable mass production, and flexible packaging options to meet diverse commercial specifications.

| Parameter | Details |
| Product Name | Polyquaternium-51 |
| Appearance | Clear to pale yellow viscous liquid / Powder |
| Purity / Grade | Cosmetic Grade / Raw Material |
| CAS Number | 125275-25-4 |
| Sample | Available (5g - 20g on request) |
| Molecular formula | C₁₉H₃₆NO₈P |
| EINECS |
433-120-0 |
| Storage | Store in a cool, dry place away from direct sunlight |
| Refractive index | No fixed standard value |
Detailed Information

What makes Polyquaternium-51 superior for moisture retention?
Polyquaternium-51 features a phospholipid polar group that mirrors the natural cell membrane structure of human skin. This allows the molecule to integrate seamlessly with the stratum corneum, creating a resilient biomimetic membrane. Unlike conventional humectants that simply draw moisture from the air, this ingredient actively locks in hydration and prevents transepidermal water loss (TEWL) even under low-humidity conditions.
Formulators choose this compound because it provides long-lasting hydration without leaving a heavy or greasy residue. Its dual hydrophilic and hydrophobic properties enable it to remain bound to the skin or hair cuticle through multiple rinse cycles, ensuring sustained performance in daily-use cosmetic formulations.

How does Polyquaternium-51 enhance hair care products?
In hair care applications, Polyquaternium-51 acts as an exceptional conditioning agent that repairs damaged cuticles and improves overall manageability. It adsorbs effectively onto the hair shaft, forming a protective shield that guards against thermal styling damage, UV exposure, and environmental pollution.
Brands incorporate this ingredient into shampoos, conditioners, and leave-in treatments to reduce frizz, enhance combability, and restore natural shine. Because it does not cause heavy buildup, it is particularly effective for fine or damaged hair types requiring lightweight structural repair.

How do we ensure batch consistency and regulatory compliance?
At Xi'an Hao Ze Bio Technology Co., Ltd., quality assurance is integrated into every stage of production, from raw material selection to final packaging. Our manufacturing facilities operate under strict quality management systems to guarantee that every batch of Polyquaternium-51 powder meets high international purity and safety standards.
We provide comprehensive documentation, including Certificates of Analysis (CoA) and Material Safety Data Sheets (MSDS), to support our clients' regulatory filing and product registration requirements worldwide, ensuring seamless integration into your supply chain.
1. Consumer Demand & Market Positioning
Modern consumers increasingly seek functional cosmetics backed by science, driving high demand for biomimetic ingredients that support skin barrier health. Polyquaternium-51 addresses this need directly by offering scientifically proven moisturization and anti-irritation properties. Incorporating this ingredient allows emerging and established beauty brands to position their skincare and hair care lines in the premium, clinical-efficacy segment of the market.
2.Flexible Formulation Compatibility
One of the primary advantages of this raw material is its exceptional compatibility with a wide range of cosmetic ingredients, including surfactants, emulsifiers, and active botanicals. It remains stable across broad pH and temperature ranges during manufacturing, allowing R&D teams to formulate complex serums, creams, and lotions without risking phase separation or loss of viscosity.
3. Bulk Supply Stability & Scalability
For global cosmetic manufacturers, supply chain continuity is critical. Our production capacity ensures reliable, year-round availability of bulk Polyquaternium-51, shielding your brand from seasonal raw material shortages. We maintain robust inventory levels and optimized logistics networks to deliver large-scale orders efficiently to destinations worldwide.
Why Choose Us
○ Decades of industry experience in botanical extraction and chemical synthesis.
○ Stringent quality control with batch-specific Certificates of Analysis (COA) and HPLC testing.
○ Robust manufacturing capacity ensuring continuous, uninterrupted product supply.
○ Dedicated customer support offering sample availability and full technical documentation.


Deliver & Shipping
We support worldwide delivery through fast express services including DHL, FedEx, and UPS for sample parcels and urgent orders. Bulk commercial shipments are efficiently handled via air freight or ocean transport, complete with standard export documentation and customs clearing support.

Contact Us
For product specifications, sample requests, or custom OEM quotes, please reach out to our commercial team:
Email: haozebio2014@gmail.com
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