What’s Urolithin A?

What's urolithin A?

Urolithin A is an intestinal metabolite of ellagic acid with antioxidant and anti-proliferative effects. The IC50 values of inhibiting T24 and cacO-2 cell growth were 43.9 and 49 μM.

What's the function of Urolithin A?

1. Urolitin A relieves muscle atrophy in the elderly

Urolitin A improves muscle loss, according to A new randomized clinical trial. Urolitin A supplements increased muscle endurance in skeletal muscles and significantly improved hands and legs.

2. Help to lose weight

Not only does urolitin A protect muscle, recent research has found that urolitin A actually affects cellular lipid metabolism and fat production. It reduces triglyceride accumulation and fatty acid oxidation, as well as the expression of genes related to fat production.

3. Urolitin A activates mitochondrial autophagy

Urolitin A's protection against muscle loss is only recently discovered, and previous studies have focused on mitochondria, particularly mitochondrial autophagy. (Mitochondrial autophagy refers to the selective removal of damaged mitochondria through the autophagosome)

UA can activate mitochondrial autophagy through a variety of ways, such as activating enzymes promoting mitochondrial autophagy, regulating mitochondrial autophagy pathways, and promoting autophagosome formation.

4. Anti-inflammatory effects

Among all clinical models of UA, there was a common effect of reduced inflammatory response.

This effect was first observed in rats with enteritis, where both mRNA and protein levels of the inflammatory marker cyclooxygenase-2 were reduced.

Other markers of inflammation, such as proinflammatory factors and tumor necrosis factor, were also found to be reduced to varying degrees as more research was conducted.

The anti-inflammatory effects of UA are multifaceted. Firstly, UA is abundant in the intestinal tract, so inflammatory bowel disease is the most effective. Including acute enteritis, ulcerative colitis, and even colon cancer.

Second, UA does more than protect against intestinal inflammation, because it reduces overall serum levels of inflammatory factors. In theory, UA can play a role in all inflammatory diseases.

5. Improve metabolic diseases

In fact, the anti-inflammatory effects of urolitin A and the activation of mitochondrial autophagy are already very effective in alleviating the symptoms of metabolic diseases.

But it also has a powerful effect, which is to improve oxidative stress, scavenging free radicals, inhibiting oxidase enzymes, and enhancing cellular antioxidant/source. Many medical experts believe that those health benefits are due to UA's antioxidant properties.

This is clinically important because aging and most age-related diseases are fundamentally associated with chronic low-grade inflammation and oxidative stress.

Once oxidative stress and inflammation were suppressed, almost all age-related diseases, such as neuroinflammation, cardiovascular disease and metabolic disease, improved.

How to supplement to Urolithin A?

We cannot get urolitin A directly from food, but it can supplement its precursor ellagic tannin.

Common foods rich in ellagic acid and ellagic tannins include pomegranate, raspberries, blueberries, blackberries, walnuts, pistachios, pecans, and some teas and aged wines and spirits.

Low sugar blackberries and blueberries are ketogenic friendly, and nuts are also good.

Moreover, it is not just the raw material that determines the bioavailability of urolixin A, but also the composition of the intestinal flora, and it is hard to say which flora is useful, with unknown results.

While we can supply Urolithin A with a very good price, if you need, just contact us freely by email: info@haozbio.com