Minocycline Hydrochloride

1.Product name: Minocycline hydrochloride
2.Appearance:White powder
3.Molecular Formula: C23H28ClN3O7
4.Molecular Weight:493.94
5.CAS No.: 1078-21-3
6.Purity: 99%
7.Test Method: HPLC
8.Payment method: TT, Western Union,Paypal,Pingpong,Xtransfer,ect.
9.Shelf Life: 2 years

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Description

Product Introduction

Minocycline hydrochloride, also known as "dimethylaminotetracycline" or "memantine", is a broad-spectrum tetracycline antibiotic. It binds to the tRNA, which is responsible for its bacteriostatic effect. Minocycline hydrochloride has a broader spectrum of antibacterial activity than similar drugs. Because of its long half-life, Minocycline hydrochloride's blood concentration is two to four times higher than other drugs in its class.
Minocycline hydrochloride is a new semi-synthetic tetracycline with high efficiency, fast-acting and long-acting, and its antibacterial spectrum is similar to that of tetracycline. Tetracycline-resistant Aureus, Streptococcus, and Escherichia coli are still sensitive to this product. Clinically, it is mainly used for urinary tract infections, gastrointestinal infections, gynecological infections, pyoderma, eye and ear, nose and throat infections, osteomyelitis and so on.

Product Photo and action

Minocycline hydrochloride

Product Specification

Minocycline hydrochloride

Product Function

Minocycline hydrochloride is an orally effective semi-synthetic tetracycline antibiotic that crosses the blood-brain barrier.Minocycline hydrochloride is a hypoxia-inducible factor (HIF-1α) inhibitor.Minocycline hydrochloride is an anti-carcinogen, anti-inflammatory and glutamate antagonist. Minocycline hydrochloride has anticancer, anti-inflammatory and glutamate antagonistic effects. Minocycline hydrochloride decreases glutamate neurotransmission and displays neuroprotective properties and antidepressant effects. Minocycline hydrochloride inhibits bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome, resulting in bacteriostatic effects.

Production Methods

A method for the preparation of minocycline hydrochloride, comprising the following steps: 1) Preparation of sanguinarine: A. Preparation of 7-dechlorohydrochloric acid desmethyl aureomycin: 7-dechlorohydrochloric acid desmethyl aureomycin was dissolved in ethanol, triethylamine and palladium carbon were added, and a reaction was carried out under the condition of hydrogen as a protective gas, and the reaction solution was filtered to obtain a filter cake, and then the cake was washed with ethanol, and dried to obtain 7-dechlorohydrochloric acid desmethyl aureomycin; B, Preparation of santonin: 7-dechlorohydrochloric acid desmethyl chlortetracycline, methanol, p-toluenesulfonic acid was mixed and dissolved at -5 ℃, rhodium carbon was added, and the reaction was carried out under the condition of hydrogen as a protective gas, and the reaction solution was lowered to 5 ℃, and triethylamine was added to the slurry to be dissolved, and the reaction solution was filtered and washed with methanol, the filtrate was collected, and the pH of the filtrate was adjusted to 1.0 by adding concentrated hydrochloric acid at -5 ℃, the filtrate was filtered to obtain the cake. After that, the filter cake was washed with methanol and dried to obtain santol; 2) preparation of 7-iodosantoin: take 5 wt. portions of strong acid sulfuric acid, 1 wt. portion of santol, 1 wt. portion of N-iodosuccinimide, dissolve the santol in the strong acid at 10 ℃, and then the reaction was moved to a low-temperature environment of 0 ℃, add N-iodosuccinimide, and the reaction was stirred for 2 h. The end point of the reaction of step 2) was as follows: the reaction liquid was measured by HPLC, and the reaction solution was found to be in a low temperature environment of -5℃. HPLC detection of the reaction solution, when the content of cyclamen is less than 3% to end the reaction. The reaction solution obtained in step 2) was mixed with 10 wt. portions of water to configure the mixture, and the mixture was flowed through a separation column equipped with 20 wt. portions of macroporous adsorbent resin within 1 hour, and then eluted with 30 wt. portions of a 35% aqueous methanol solution, and then eluted with 20 wt. portions of a 60% aqueous methanol solution, and eluent containing the target component was collected; the eluent was concentrated under reduced pressure at 40 °C, and the precipitated The solid was filtered and dried under reduced pressure at 30 ℃ for 5 hours to obtain 7-iodosaniline; 3) preparation of minocycline hydrochloride: 1 wt. of 7-iodosaniline, 10 wt. of N,N-dimethylformamide, 0.01 wt. of bis(triphenylphosphine)dichloropalladium was dissolved with stirring at 50 ℃, and then 0.3 wt. of dimethylamino-trimethylstannane and 0.5 wt. of triethylamine were added. The reaction was stirred for 6 h. The end point of the reaction in step 3) was that the reaction solution was detected by HPLC, and the reaction was ended when the content of 7-iodosanillin was less than 2%. The reaction solution obtained in step 3) was flowed through a separation column equipped with 20 wt. portions of macroporous adsorbent resin within 2 hours, and then eluted sequentially with 20 wt. portions of water, 40 wt. portions of 20% aqueous methanol solution, and 10 wt. portions of 80% methanol solution, and the eluate containing the target component was collected, and the eluate was concentrated under reduced pressure and then adjusted the pH of the reaction solution to 1.0 with concentrated hydrochloric acid, while the reaction solution was then decolored with activated carbon. After that, the pH of the reaction solution was adjusted to 3.8 with ammonia, freeze crystallization was performed, and the filter cake was dried after filtration to obtain minocycline hydrochloride.

Product Application

Clinically, it is mainly used for respiratory, urinary, skin and soft tissue infections caused by drug-resistant bacteria, as well as meningitis and its carriers, chronic osteomyelitis, cholecystitis, gonorrhea and so on.

Minocycline hydrochloride