Angiotensin II Receptor Antagonist (ARB) Antihypertensive Drugs

Angiotensin II receptor antagonists are a recently introduced class of antihypertensive drugs.

Angiotensin II (ANG II) plays a major role in the occurrence and development of hypertension, arteriosclerosis, cardiac hypertrophy, heart failure, diabetes, and kidney disease.

Angiotensin-converting enzyme inhibitor (ACEI) partially blocks the formation of ANG Ⅱ, which has a significant therapeutic effect on the above-mentioned heart, kidney and other diseases, but some patients cannot tolerate it due to side effects such as dry cough. II-effect angiotensin II receptor antagonist (ARB). Angiotensin II receptor antagonists act on the receptor level and can inhibit the production of ANG II by various pathways. Therefore, it can inhibit RAS more effectively than ACE inhibitors.

There are as many as 12 angiotensin Ⅱ receptor antagonists reported in clinical application at present, among which losartan is the most used, followed by valsartan.

Angiotensin II receptor antagonists are a promising new class of antihypertensive drugs and have been recommended as first-line antihypertensive drugs by WHO/ISH.