Quercetin & Covid, Do They Have Connections?

1.What’s quercetin?

Quercetin is an expectorant commonly used in clinical practice in Traditional Chinese medicine. It has good expectorant and cough relieving effects, as well as certain antiasthmatic effects, and has the pharmacological functions of lowering blood pressure, improving capillary resistance, reducing capillary fragility, lowering blood lipid, expanding coronary Chemicalbook artery and increasing coronary blood flow. Clinical quercetin is mainly used for bronchitis and phlegm inflammation. It also has auxiliary therapeutic effect on patients with coronary heart disease and hypertension. Dry mouth, dizziness and burning sensation in stomach area may occur with this product, which will disappear after withdrawal.

2.What’s the Pharmacological effects of quercetin?

Quercetin can inhibit the growth of malignant cells and DNA, RNA and protein synthesis of ascites cancer cells in vitro. Quercetin can inhibit platelet aggregation and the release of 5-ht Chemicalbook, and has significant inhibition on PLATELET aggregation induced by ADP, thrombin and platelet activating factor (PAF), among which, it has the strongest inhibition on PAF, and can also significantly inhibit the release of rabbit platelet 3H-5-HT induced by thrombin.

3.Whats's the effects of quercetin?

Quercetin, as the most common flavonoid, has a variety of biological activities, antioxidant, and plays an important role in the clinical treatment of cancer and cardiovascular diseases. Antioxidant function Quercetin is not only involved in antioxidant activity in vitro, which inhibits DNA oxidative damage, but also protects tissues from oxidative damage in vivo by reducing peroxide concentration in tissues. On the one hand, quercetin can effectively inhibit the production of free radicals. Its flavonoids such as quercetin can significantly reduce the incidence of gastric cancer, directly inhibit the growth of cancer cells or may act on the cell transduction pathway of cancer cell proliferation. On the other hand, it can enhance the effect of anti-cancer drugs, significantly improving the effectiveness of the drug. Cardiovascular protection The third major effect of quercetin is cardiovascular protection. Mainly reflected in five aspects: dilate blood vessels, reduce blood pressure; Prevention and treatment of coronary Chemicalbook disease: through animal experiments, it has been found that it can reduce the incidence and mortality of myocardial infarction and reduce blood glucose. Reduce myocardial hypertrophy; Inhibit vascular smooth muscle cell hypertrophy; Antithrombotic. In addition, quercetin also has neuroprotective, anti-inflammatory and antiviral effects. Anti-inflammatory action: Lipopolysaccharide (LPS) can cause immune responses and inflammation when the body's immune system fights bacterial invasion. Some studies have shown that quercetin has an inhibitory effect on lPS-induced inflammation. Antibacterial action: quercetin is also a broad-spectrum antibacterial substance, which can be used to prevent and cure various bacterial infections. Antiviral action: Quercetin can fight a variety of viruses, such as HIV, anti-sarcoma virus, human herpes simplex virus, parainfluenza virus type 3 (PF-3), respiratory syncytial virus (RSV).

4.Does quercetin have effect on covid?

The first Affiliated Hospital of Tianjin University of Traditional Chinese Medicine conducted a study, which screened the active components and targets of Lianhua Qingping by using TCMSP, TCMID database and relevant literature. The results showed that a total of 378 active components, 282 potential targets, and 55 common targets with 2019-NCOV were obtained after screening, indicating that there are 55 novel coronavirus targets that can definitely act on The Virus, confirming that the drug has a definite therapeutic effect on COVID-19. The study also found that there were 22 key compounds, including quercetin, aloe emodin and hanbaicalein, among which the degree value of quercetin was the largest and the number of targets was the largest, indicating that the effect of quercetin might be the most significant. Quercetin has anti-inflammatory, antiviral and immunomodulatory pharmacological effects. It is also the main component of forsythia and Honeysuckle.

So that means, at least quercetin could help some for treating covid and could reduce the symptom.

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