Synthesis Method And Use Of Chlorzoxazone

Clozoxazone is an oral effective central skeletal muscle relaxant with a completely different chemical structure from all other muscle relaxants. It mainly acts on the spinal cord and subcortical centers of the brain, inhibiting the multi-synaptic reflex associated with muscle spasms, resulting in muscle relaxation, alleviating pain caused by spasms, and increasing the flexibility of affected muscles. Acetaminophen is a non steroidal antipyretic and analgesic drug that may have analgesic and antipyretic effects mainly by inhibiting the synthesis of prostaglandins. Studies on the muscle relaxant effect of the net climbing method in mice have shown that compound chlorzoxazone exhibits a significant dose dependent muscle relaxant effect and has a good protective effect on strychnine induced seizures in mice. The presence of paracetamol in compound chlorzoxazone tablets can enhance the effect of chlorzoxazone. The hot plate analgesic test showed that compound chlorzoxazone had a significant analgesic effect in a dose dependent manner, and also had a significant antagonistic effect on the painful writhing reaction induced by potassium antimony tartrate in mice, showing a good dose effect relationship. The experimental results showed that acetaminophen and chlorzoxazone had a synergistic analgesic effect.

Synthesis method of chlorzoxazone:
Using 2,5-dichloronitrobenzene as raw material, 2-amino-4-chlorophenol was obtained through hydrolysis and reduction reactions, followed by cyclization in hydrochloric acid to obtain chlorzoxazone in an overall yield of 84%.

1. The reaction of pyrimidinyl imidazolyl ethanol (MAIE) with 2-chloro-3-acetylaminopropionic acid under alkaline conditions yields 2 - (2-pyrimidinyl imidazol-1-yl) - 3-acetylaminopropionic acid (MAIMP).
2. Reaction of MAIMP with sodium nitrite or ammonium nitrite to produce a precursor compound of chlorzoxazone.
3. chlorzoxazone was obtained through a reduction reaction.

Use of chlorzoxazone:
Chlorzoxazone tablets are a kind of analgesic and anti-inflammatory drug. Its main ingredient is chlorzoxazone, which is a skeletal muscle relaxant. It mainly acts on the spinal cord and subcortical centers of the brain to inhibit the multiple process reflex associated with muscle spasms, thereby relaxing the muscles, alleviating pain, and increasing the flexibility of affected muscles.
Clozoxazone is a broad-spectrum antibacterial drug that can be used to treat drug-resistant infections, especially drug-resistant Staphylococcus aureus infections, C Infectious infection, pneumonia, diarrhea and other infectious diseases.
In addition, chlorzoxazone can also be used for the treatment and prevention of digestive system diseases.

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