Isosorbitol

Product Introduction:

 

This product is a derivative of dehydration of sorbitol, oral osmotic dehydration and diuresis medicine, the mechanism is similar to the intravenous injection of mannitol and sorbitol. By increasing the osmotic pressure of the plasma, the tissue (including the eye, brain, cerebrospinal fluid, etc.) into the blood vessels, thereby reducing tissue edema, reduce intraocular pressure, intracranial pressure and cerebrospinal fluid volume and pressure. Can be used as pharmaceutical intermediates, synthetic plastic resin additives, feed additives.

 

Isosorbide is an effective and long-acting nitrate anti angina drug, which is the same as nitroglycerin. It is mainly used to prevent seizures before the heart and can be used to relieve symptoms.

Coronary artery dilator is used for the treatment of angina pectoris.
1. DTPA 99%min (Diethylenetriaminepentaacetic Acid, CAS: 67-43-6) is primarily used as a metal ion chelator.

2. DTPA 99%min (Diethylenetriaminepentaacetic Acid, CAS: 67-43-6) has found countless applications in many industries, such as papermaking, textiles, food, medicine, agriculture, daily necessities, and others.

 

 

Details:

Product Name:	Isosorbide dinitrate
Synonyms:	1,4:3,6-dianhydro-,dinitrate,d-glucito;1,4:3,6-dianhydro-d-glucitodinitrate;1,4:3,6-dianhydrosorbitol2,5-dinitrate;cardis;carvanil;carvasin;[(3S,3aS,6R,6aS)-6-Nitrooxy-2,3,3a,5,6,6a-hexahydrofuro[2,3-d]furan-3-yl] nitrate;Isosorbitol dinitrate
CAS:	87-33-2
MF:	C6H8N2O8
MW:	236.14
EINECS:	201-740-9
Product Categories:	chiral;Nitric Oxide Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:	87-33-2.m

Function：

Similar to other nitrites and organic nitrates, isosorbide dinitrate is converted to nitric oxid e (NO), an active intermediate compound which activates the enzyme guanylate cyclase (atrial natriuretic peptide receptor A). This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.

Application：

Absorption of isosorbide dinitrate after oral dosing is nearly complete, but bioavailability is highly variable (10% to 90%), with extensive first-pass metabolism in the liver. The average bioavailability of isosorbide dinitrate is about 25%.

 

 

Photo:

Packaging & Delivery:

1-20kg weight, use foil bag and & master carton, ship by express.

20-25kg weight, use drum or master carton, ship by express.

Over 100kg, we can ship by sea.

FAQ:

1. Can I get some free sample?

Yes, we offer free sample of Losartan to client but the shipping cost will be paid by client.

2.How to make payment and what is the payment term?

Payment can be done by bank, credit card, Western Union, PayPal, etc.

3. How does your factory ensure product quality?

First of all, we have about 10 years experience in this field, and we already have mature quality control procedures. In addition, we will conduct the most thorough inspection before shipment.

4. Can you do OEM for me?

We accept OEM orders, just contact us and send us your request. We will give you a reasonable price and make samples as soon as possible.

5. How to get in touch with us?

You can chat with us via email, Skype and Whats App, or simply send us an email or phone call. All our contacts are shown in website.

 

We can provide most API materials for customers. If you have any questions or would like more information, please contact us by email: info@haozbio.com

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