Shikonin/Alkanin--New Popular Product in Anti-cancer Field

What is Shikonin/Alkanin?

Shikonin is a kind of organic matter, chemical formula is C16H16O5, with insoluble in water, soluble in ethanol, organic solvents and vegetable oil, soluble in alkali water, acid and precipitation. It is purplish red naphthoquinone natural pigment extracted from the natural plant Zongfugen. The main components are Porphyroquinone and its title organisms. Including Shikonin, acetochrome, B, P '-dimethylacryl Shikonin (P, P '-dimethylacryl Shikonin), P hydroxyisovaleryl Shikonin (P-hydaro-xyisovaleryl Shikonin), isovaleryl Shikonin, deoxy Shikonim, etc

Product Specification

What’s the Function of Shikonin?

(1) Hypoglycemic effect The extracts of Lithosperms leaves and comfrey polysaccharides (A, B, C) all had obvious hypoglycemic effect.

(2) Bacteriostatic effect S. chinensis has inhibitory effect on jingke 68-1 virus in test tube and staphylococcus aureus. The effects of levochromatin on parainfluenza virus were studied by hemagglutination reaction and cytopathic assay. The results showed that levochromatin had low toxicity in the range of concentration used in the experiment, and had certain anti-influenza virus activity in vitro and direct killing of parainfluenza virus.

(3) Effect on hemagglutination Intraperitoneal injection of the pigment components (Shiverin, acetoshiverin) did not affect the blood coagulation time, but could prevent the anticoagulant effect of heparin.

(4) Antitumor effect The extract of S. chinensis could inhibit the late DNA synthesis (G2 phase) of Hela cells.

(5) Anticancer effect Shiverin inhibits proliferation, promotes apoptosis and induces cell cycle arrest of human choriocarcino-resistant cell line (JAR/MTX) cultured in vitro. Experimental results showed that the inhibition rate of shiverin on the growth of choriocarcino-resistant cell line increased significantly with the increase of Chemicalbook concentration and the extension of action time.

(6) Effect of Shiverin on the function of hypothalamic-pituitary-gonad axis in adolescent female rats. The results showed that the serum hormone level in Shiverin group was significantly lower than that in negative control group, and there was no significant difference compared with positive control group. The results showed that shikonin inhibited the function of hypothalamic-pituitary-gonad axis in rats.

(7) Antioxidant activity The scavenging ability of The pigment on superoxide free radical (O2-) and 1, 1-diphenyl-2-picrhenazid free radical (DPPH) and its inhibitory effect on the autooxidation system of β -carotene/linoleic acid were determined. The results showed that the pigments of S. chinensis had strong scavenging ability on DPPH and O2-, and inhibited β -carotene/linoleic acid autooxidation system, suggesting that the pharmacological action of S. chinensis might be related to the strong antioxidant ability of naphthoquinone pigments.

Application

Shikonin could be used in medical, health care,cosmetic and food field.

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