What Is Lidocaine？

Lidocaine is a local anesthetic and anti-arrhythmia drug. It is a derivative of cocaine, but has none of the hallucinogenic and addictive ingredients of cocaine. Lidocaine hydrochloride is a white crystalline powder, which is very slightly dissolved in water. Its toxicity is similar to procaine, but the effect of local anesthesia is strong and lasting, with good surface penetration. It can be injected or used as surface anesthesia. Lidocaine is a very good local anesthetic that takes effect one to three minutes after application and lasts one to three hours. Used to treat canker sores. It has been used less often as a heart rhythm disorder drug because of concerns about long-term side effects. A few people are allergic to lidocaine. In 1963, it was used for the treatment of arrhythmia. It is the drug for preventing and treating acute myocardial infarction and various heart diseases complicated with rapid ventricular arrhythmia. It is the first choice for premature ventricular beat, ventricular tachycardia and ventricular tremor of acute myocardial infarction.

This product is an amide local anesthetic. After blood absorption or intravenous administration, the central nervous system has obvious excitatory and inhibitory biphasic effect, and there can be no pioneer excitement, when blood drug concentration is low, analgesia and lethargy, pain threshold increase; With the increase of dosage, the effect or toxicity is enhanced, subtoxic blood concentration has anticonvulsant effect; Convulsion may occur when the plasma concentration exceeds 5mg· ml-1. At low dose, this product can promote K+ outflow in myocardial cells, reduce the self-discipline of myocardium, and has the effect of anti-ventricular arrhythmia; There was no significant effect on the electrical activity of myocardial cells, atrioventricular conduction and myocardial contraction at the treatment dose. Blood drug concentration increases further, can cause the heart conduction velocity to slow down, atrioventricular conduction block, inhibit myocardial contractility and make cardiac output decreased.

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