What Is Nattokinase?

what is Nattokinase？

1.Nattokinase is an enzyme extracted from nattō, a popular Japenese breakfast dish made from fermented soybeans. Nattō has long been used in folk medicine to treat cardiovascular diseases; nattokinase is believed to possess the same properties.

2.Nattō, known for its strong, cheese-like smell and sticky consistency, is made by adding the bacterium Bacillus subtilis natto to boiled soybeans and leaving it until fermented. The only source of nattokinase is nattō, and it can only be produced using this specific fermentation process.

3.The extracted enzyme is manufactured into capsules and tablets, although it can also be found in powdered form in Japan. While generally considered safe and tolerable, nattokinase may cause side effects and interact with certain medications.

What Is Nattokinase Used For?

In alternative medicine, nattokinase is believed to benefit people with heart and vascular diseases, in part by breaking down blood clots that can impede circulation. Among the conditions nattokinase is purported to prevent or treat are:

1.Angina

2.Atherosclerosis

3.Deep vein thrombosis (DVT)

4.Hemorrhoids

5.Hypertension (high blood pressure)

6.Myocardial infarction (heart attack)

7.Peripheral artery disease (PAD)

8.Stroke

9.Varicose veins

Dosage and Preparation

1.In the United States, nattokinase is found almost exclusively in capsule or tablet form. Doses are often indicated in fibrin units (FU), with 2,000 FU translating to roughly 100 milligrams (mg) and 3,000 FU translating to 150 mg.

2.There are no universal guidelines for the appropriate use of nattokinase. Doses of up to 3,000 FU have been used safely for up to 26 weeks,4 although most manufacturers recommend no more than 2,000 FU per day.

3.In addition to supplements, you can also obtain nattokinase by adding nattō to your diet. There are small producers in the United States who ship fresh nattō directly to consumers and health food stores. You can also make your own by purchasing Bacillus subtilis natto spores online.

The main function;

A significant function of nattokinase is to dissolve thrombosis. Mimugu F et al. determined the fibrinolytic activity of nattokinase by blood clot lysis assay, and compared it with Plasmin, and found that the fibrinolytic activity of nattokinase was 4 times that of Plasmin; MiLsugu.

When nattokinase was injected intravenously into a chemically induced and synthesized thrombus model, significant thrombolysis was found, and it showed a higher fibrinolytic capacity than plasmin and elastase. The above studies have shown that nattokinase has strong fibrinolytic activity both in vitro and in vivo. Nattokinase can also activate plasminogen in vivo, thereby increasing the amount of endogenous plasmin. in addition. After oral administration of nattokinase in healthy people, the following effects occurred:

① Significantly shorten the dissolution time (ELT) of euglobulin;

② Increased fibrinolytic activity in plasma;

③ The amount of t-PA in plasma increased. Due to the safety, stability and good thrombolytic effect of NK, it has the potential to be used as an oral agent for thrombosis therapy